Andersen Tawil Syndrome

Andersen Tawil Syndrome may be caused by potassium channels in the muscle not working as well as they should.

  • The reason they don’t work so well is because of a ‘mistake’  in the gene that makes the potassium channel
  • This gene is called KCNJ2
  • This gene is found in muscle, brain, bone, nerve and the heart so it is important to check for other symptoms.

What symptoms can be experienced?

  • Attacks of paralysis or weakness
  • Muscle twitching
  • Cramps
  • Palpitations
  • Syncope (fainting spells)
  • Some changes in bone structure and facial features from birth

How can Andersen Tawil syndrome affect the heart?

Heart symptoms can sometimes occur in people with Andersen Tawil Syndrome. The symptoms can include palpitations, shortness of breath or chest pain. More rarely, some people can have syncope (faints). In very rare cases patients may have to have a special type of pacemaker fitted. Some people may not have any cardiac symptoms.

It is important to detect any trouble with the heart.

We recommend:

  • Yearly review with a Cardiologist who is familiar with Andersen Tawil Syndrome
  • Yearly cardiac holter monitors (a prolonged recording of your heart rhythm that is done at home)

The frequency of this may vary depending on your Cardiologist.

It is important for other doctors and your GP to be aware of this also and sometimes a letter from us explaining Andersen Tawil Syndrome can be helpful.